General Research
Remote Ischemic Conditioning (RIC)
The field of remote ischemic conditioning is an expanding area of general biological research. This research continues to build on the established knowledge base associated with reperfusion injury of our body's organs and the understanding of remote ischemic conditioning as a mechanism to mitigate this damage.
PUBLISHED ARTICLES:
Potent neuroprotection induced by remote preconditioning in a rat model of neonatal cerebral hypoxic–ischemic injury
Askalan R; Dai X; Li J; Redington AN; Shi H; Tropak MB / Tropak et al. JTCVS 2011
Remote preconditioning provides potent cardioprotection via pi3k/akt activation and is associated with nuclear accumulation of beta-catenin.
Li J, Xuan W, Yan R, Tropak MB, Jean-St-Michel E, Liang W, Gladstone R, Backx PH, Kharbanda RK, Redington AN. / Clin Sci (Lond). 2011;120:451-462
Heart Disease and Stroke Statistics2011 Update: A Report From the American Heart Association
Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, De Simone G, Donald LJM, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Go AS, Greenlund KJ, Hailpern SM, Heit JA, Ho M, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, McDermott MM, Meigs JB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Roger VL, Rosamond WD, Sorlie PD, Stafford RS, Turan TN, Turner MB, Wong ND, Wylie-Rosett J / Circulation 2011;123;e18-e209
The therapeutic potential of ischemic conditioning: an update
Hausenloy DJ, Yellon DM / Doi:10.1038/nrcardio.2011.85 (AKA "The Nature Review")
Pretreatment with the nitric oxide donor snap or nerve transection blocks humoral preconditioning by remote limb ischemia or intra-arterial adenosine.
Steensrud T, Li J, Dai X, Manlhiot C, Kharbanda R, Tropak MB, Redington AN. / Am J Physiol Heart Circ Physiol. 2010
ST changes before and during primary percutaneous coronary intervention predict final infarct size in patients with ST elevation myocardial infarction.
Anderson HR; Bøtker HE; Bøttcher M; Clarsen K; Kaltoft AK; Lassen JF; Nielsen SS; Nielsen TT; Nørgaard BL; Terkelsen CJ; Thuesen L / J Electrocardiol 2009;42:64-72
Translation of remote ischaemic preconditioning into clinical practice.
Kharbanda RK, Nielsen TT, Redington AN. / Lancet. 2009;374:1557-1565
Transient limb ischaemia remotely preconditions through a humoral mechanism acting directly on the myocardium: Evidence suggesting cross-species protection.
Shimizu M, Tropak M, Diaz RJ, Suto F, Surendra H, Kuzmin E, Li J, Gross G, Wilson GJ, Callahan J, Redington AN. / Clin Sci (Lond). 2009;117:191-200
Relation of Troponin I Levels Following Nonemergent Percutaneous Coronary Intervention to Short- and Long-Term Outcomes
Bergman G; Feldman DN; Minutello RM; Moussa I; Wong SC / Am J Cardiol 2009;104:1210–1215
Surgical Tourniquets in Orthopaedics
Eisen A.; Col. Kragh JF Jr.; Masri BA; McEwen JA; Noordin S / J Bone Joint Surg Am. 2009;91:2958-2967
Remote ischemic preconditioning decreases adhesion and selectively modifies functional responses of human neutrophils.
Shimizu M, Saxena P, Konstantinov IE, Cherepanov V, Cheung MM, Wearden P, Zhangdong H, Schmidt M, Downey GP, Redington AN. / J Surg Res. 2008
Troponin I after cardiac surgery and its implications on myocardial protection, outcomes, and cost
Crittenden MD; Gibson S; Haime M; Healey NA; Khuri SF; Rousou LJ; Taylor KB; Thatte HS / The American Journal of Surgery (2008) 196, 703–709
Preconditioning and postconditioning: innate cardioprotection from ischemia-reperfusion injury
Dobson GP, Jiang R, Vinten-Johansen J, Zatta AJ, Zhao ZQ / J Appl Physiol 103:1441-1448, 2007
Routine Thrombectomy in Percutaneous Coronary Intervention for Acute ST-Segment–Elevation Myocardial Infarction A Randomized, Controlled Trial
Andersen HR; Bøtker HE; Bøttcher M; Hansen HHT; Kaltoft A; Kristensen J; Kristensen SD; Krusell LR; Lassen JF; Mæng M; Nielsen SS; Nielsen TT; Rasmussen K; Rehling M; Terkelsen C; Thuesen L / Circulation. 2006;114:40-47
The remote ischemic preconditioning stimulus modifies gene expression in mouse myocardium.
Konstantinov IE, Arab S, Li J, Coles JG, Boscarino C, Mori A, Cukerman E, Dawood F, Cheung MM, Shimizu M, Liu PP, Redington AN. / J Thorac Cardiovasc Surg. 2005;130:1326-1332
The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans.
Konstantinov IE, Arab S, Kharbanda RK, Li J, Cheung MM, Cherepanov V, Downey GP, Liu PP, Cukerman E, Coles JG, Redington AN. / Physiol Genomics. 2004;19:143-150
Does preconditioning protect the coronary vasculature from subsequent ischemia/reperfusion injury?
Bauer B; Kloner RA; Przyklenk K; Simkhovich BZ / Circulation 1993;88;659-672
Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold-blood cardioplegia: a randomised controlled trial
V Venugopal, D J Hausenloy, A Ludman, C Di Salvo, S Kolvekar, J Yap, D Lawrence, J Bognolo, D M Yellon
Remote Ischemic Limb Preconditioning After Subarachnoid Hemorrhage
Sebastian Koch, MD, Michael Katsnelson, MD, Chuanhui Dong, PhD, and Miguel Perez-Pinzon, PhD
Remote Ischemic Preconditioning Making the Brain More Tolerant, Safely and Inexpensively
Michael A. Moskowitz, MD; Christian Waeber, PhD
AHA Heart & Stroke Facts 2003
American Heart Association
Heart & Stroke Statistics: 2010 Update At-A-Glance
American Heart Association
CURRENT TRIALS:
Europe / The Effect of Ischaemic-Reperfusion and Remote Ischaemic Preconditioning in Man - A Bradykinin Dependent Pathway
Rajesh K Kharbanda, PhD
David E Newby, PhD / Clinicaltrails.gov ID NCT00965393
Europe / The Effects of Preconditioning on Intramuscular High-Energy Phosphate Levels During Ischemia
Prof. Dr. Michael Wolzt / Clinicaltrails.gov ID NCT00883467
Asia / Study on the Cardioprotection and Humoral Mechanism of Limb Ischemia Preconditioning
Guangdong Natural Science fund Committee / Clinicaltrails.gov ID NCT01118000