Published Articles
All Regions
Published articles on RIC from around the world...
Urban and rural implementation of pre-hospital diagnosis and direct referral for primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction
Andersen HR; Bøtker HE; Hansen TM; Lassen JF; Nørgaard BL; Sørensen JT; Terkelsen CJ; Trautner S
/ Sørensen et al. Eur Heart J 2011:430-6
Potent neuroprotection induced by remote preconditioning in a rat model of neonatal cerebral hypoxic–ischemic injury
Askalan R; Dai X; Li J; Redington AN; Shi H; Tropak MB / Tropak et al. JTCVS 2011
Remote Ischemic Per-Conditioning: A Novel Therapy for Acute Stroke?
Hahn CD; Manlhiot C; Nielsen TT; Redington AN; Schmidt MR / Hahn et al. Stroke 2011
Remote preconditioning provides potent cardioprotection via pi3k/akt activation and is associated with nuclear accumulation of beta-catenin.
Li J, Xuan W, Yan R, Tropak MB, Jean-St-Michel E, Liang W, Gladstone R, Backx PH, Kharbanda RK, Redington AN. / Clin Sci (Lond). 2011;120:451-462
Repeated Remote Ischemic Postconditioning Protects Against Adverse Left Ventricular Remodeling and Improves Survival in a Rat Model of Myocardial Infarction
Li J; Li J; Li S; Li Y; Liu M; Redington AN; Tao J; Wei M; Xin P; Zhu W / Circulation Research 2011, 108:1220-1225
Heart Disease and Stroke Statistics2011 Update: A Report From the American Heart Association
Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, De Simone G, Donald LJM, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Go AS, Greenlund KJ, Hailpern SM, Heit JA, Ho M, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, McDermott MM, Meigs JB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Roger VL, Rosamond WD, Sorlie PD, Stafford RS, Turan TN, Turner MB, Wong ND, Wylie-Rosett J / Circulation 2011;123;e18-e209
Effect of remote ischemic preconditioning on renal dysfunction after complex valvular heart surgery: A randomized controlled trial
Ahn KR; Choi YS; Kang K; Kim JC; Kwak YL; Seo YH; Shim JK / J Thorac Cardiovasc Surg 2011;142:148-54
Remote intermittent ischemia before coronary artery bypass graft surgery: a strategy to reduce injury and inflammation?
Chaubey S; Desai J; Dew T; John L; Karuppasamy P; Kunst G; Marber MS; Musto R; Shah AM; Sherwood R / Basic Res Cardiol (2011) 106:511–519
JACC: Initial restenosis pattern is important predictor of reintervention
Editorial Staff / JACC 2011
The therapeutic potential of ischemic conditioning: an update
Hausenloy DJ, Yellon DM / Doi:10.1038/nrcardio.2011.85 (AKA "The Nature Review")
Remote Ischemic Preconditioning: Making the Brain More Tolerant, Safely and Inexpensively
Moskowitz MA, Waeber C / Circulation. 2011;123:709-711
Remote Ischemic Conditioning in Patients With Myocardial Infarction Treated With Primary Angioplasty : Impact on Left Ventricular Function Assessed by Comprehensive Echocardiography and Gated Single-Photon Emission CT
Andersen NH; Bøtker HE; Munk K; Nielsen SS; Nielsen TT; Poulsen SH; Schmidt MR; Sloth E; Terkelsen CJ / Circ Cardiovasc Imaging 2010;3;656-662
Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: A randomised trial.
Botker HE, Kharbanda R, Schmidt MR, Bottcher M, Kaltoft AK, Terkelsen CJ, Munk K, Andersen NH, Hansen TM, Trautner S, Lassen JF, Christiansen EH, Krusell LR, Kristensen SD, Thuesen L, Nielsen SS, Rehling M, Sorensen HT, Redington AN, Nielsen TT. / Lancet. 2010;375:727-734
Limb Ischemic Preconditioning Reduces Heart and Lung Injury After an Open Heart Operation in Infants
Debing Z; Guangxian Y; Jian L; Pingbo L; Renwei C; Wenwu Z; Xinmin Z / Pediatr Cardiol (2010) 31:22–29
Remote preconditioning improves maximal performance in highly-trained athletes.
Jean-St-Michel E, Manlhiot C, Li J, Tropak M, Michelsen MM, Schmidt MR, McCrindle BW, Wells GD, Redington AN. / Med Sci Sports Exerc. 2010
Pretreatment with the nitric oxide donor snap or nerve transection blocks humoral preconditioning by remote limb ischemia or intra-arterial adenosine.
Steensrud T, Li J, Dai X, Manlhiot C, Kharbanda R, Tropak MB, Redington AN. / Am J Physiol Heart Circ Physiol. 2010
Combined local ischemic postconditioning and remote perconditioning recapitulate cardioprotective effects of local ischemic preconditioning.
Xin P, Zhu W, Li J, Ma S, Wang L, Liu M, Wei M, Redington AN. / Am J Physiol Heart Circ Physiol. 2010;298:H1819-1831
Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial
Adameka P, Bedanovac H, Freibergerd T, Grodeckad L, Pilerb P, Wagner R / Interact CardioVasc Thorac Surg 2010;11:758-762
Induced Remote Ischemic Pre-conditioning on Ischemia–Reperfusion Injury in Patients Undergoing Coronary Artery Bypass
Ali N; Iqbal A; Rashid A; Rizwi F / Journal of the College of Physicians and Surgeons Pakistan 2010, Vol. 20 (7): 427-431
The effect of remote ischaemic preconditioning on myocardial injury in patients undergoing off-pump coronary artery bypass graft surgery
Bahk JH; Hong DM; Jeon Y; Kim JH; Lim TW; Lim YJ; Min JJ; Sohn IS / Anaesth Intensive Care 2010; 38:924-929
Heart
O'Riordan M / Heart 2010
ST changes before and during primary percutaneous coronary intervention predict final infarct size in patients with ST elevation myocardial infarction.
Anderson HR; Bøtker HE; Bøttcher M; Clarsen K; Kaltoft AK; Lassen JF; Nielsen SS; Nielsen TT; Nørgaard BL; Terkelsen CJ; Thuesen L / J Electrocardiol 2009;42:64-72
Remote postconditioning is more potent than classic postconditioning in reducing the infarct size in anesthetized rabbits.
Demerouti E; Farmakis D; Gritsopoulos G; Iliodromitis EK; Kremastinos DT; Papalois A; Paraskevaidis IA; Zoga A / Cardiovasc Drug Ther 2009;23:193-8
Cardiac remote ischemic preconditioning in coronary stenting (crisp stent) study: A prospective, randomized control trial.
Hoole SP, Heck PM, Sharples L, Khan SN, Duehmke R, Densem CG, Clarke SC, Shapiro LM, Schofield PM, O'Sullivan M, Dutka DP. / Circulation. 2009;119:820-827
Translation of remote ischaemic preconditioning into clinical practice.
Kharbanda RK, Nielsen TT, Redington AN. / Lancet. 2009;374:1557-1565
Transient limb ischaemia remotely preconditions through a humoral mechanism acting directly on the myocardium: Evidence suggesting cross-species protection.
Shimizu M, Tropak M, Diaz RJ, Suto F, Surendra H, Kuzmin E, Li J, Gross G, Wilson GJ, Callahan J, Redington AN. / Clin Sci (Lond). 2009;117:191-200
Conditioning' the heart during surgery.
Venugopal V, Ludman A, Yellon DM, Hausenloy DJ. / Eur J Cardiothorac Surg. 2009;35:977-987
Prognostic Value of Troponin I Levels for Predicting Adverse Cardiovascular Outcomes in Postmenopausal Women Undergoing Cardiac Surgery
Barzilai B; Da´vila-Roma´n VG; Hogue CW; Stearns JD; Thomas B; Thompson RE / Anesth Analg 2009;108:719 –26
Relation of Troponin I Levels Following Nonemergent Percutaneous Coronary Intervention to Short- and Long-Term Outcomes
Bergman G; Feldman DN; Minutello RM; Moussa I; Wong SC / Am J Cardiol 2009;104:1210–1215
Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold-blood cardioplegia: a randomised controlled trial
Bognolo J; Di Salvo C; Hausenloy DJ; Kolvekar S; Lawrence D; Ludman A; Venugopal V; Yap J; Yellon DM / Heart 2009;95:1567–1571
Surgical Tourniquets in Orthopaedics
Eisen A.; Col. Kragh JF Jr.; Masri BA; McEwen JA; Noordin S / J Bone Joint Surg Am. 2009;91:2958-2967
Limb remote-preconditioning protects against focal ischemia in rats and contradicts the dogma of therapeutic time windows for preconditioning
Gao X; Ren C; Steinberg GK; Zhao H / Neuroscience. 2008 February 19; 151(4): 1099–1103
Remote ischemic preconditioning decreases adhesion and selectively modifies functional responses of human neutrophils.
Shimizu M, Saxena P, Konstantinov IE, Cherepanov V, Cheung MM, Wearden P, Zhangdong H, Schmidt M, Downey GP, Redington AN. / J Surg Res. 2008
Remote ischemic preconditioning elaborates a transferable blood-borne effector that protects mitochondrial structure and function and preserves myocardial performance after neonatal cardioplegic arrest.
Wang L, Oka N, Tropak M, Callahan J, Lee J, Wilson G, Redington A, Caldarone CA. / J Thorac Cardiovasc Surg. 2008;136:335-342
Troponin I after cardiac surgery and its implications on myocardial protection, outcomes, and cost
Crittenden MD; Gibson S; Haime M; Healey NA; Khuri SF; Rousou LJ; Taylor KB; Thatte HS / The American Journal of Surgery (2008) 196, 703–709
Remote ischemic preconditioning reduces myocardial and renal injury after elective abdominal aortic aneurysm repair: A randomized controlled trial.
Ali ZA, Callaghan CJ, Lim E, Ali AA, Nouraei SA, Akthar AM, Boyle JR, Varty K, Kharbanda RK, Dutka DP, Gaunt ME. / Circulation. 2007;116:I98-105
Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs
Andreka G; Andreka P; Ashrafian H; Font G; Fontos G; Frenneaux MP; Juhasz ED; Piroth Z; Szantho G; Szekely L; Szelid Z; Turner MS; Vertesaljai M / Heart 2007;93:749–752
Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: A randomised controlled trial.
Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, Ashley E, Vichare S, Di Salvo C, Kolvekar S, Hayward M, Keogh B, MacAllister RJ, Yellon DM. / Lancet. 2007;370:575-579
Myocardial Reperfusion Injury
Hausenloy DJ; Yellon DM / N Engl J Med 2007; 357:1121-1135
Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a katp-dependent mechanism: First demonstration of remote ischemic perconditioning.
Schmidt MR, Smerup M, Konstantinov IE, Shimizu M, Li J, Cheung M, White PA, Kristiansen SB, Sorensen K, Dzavik V, Redington AN, Kharbanda RK. / Am J Physiol Heart Circ Physiol. 2007;292:H1883-1890
Effects of intermittent lower limb ischaemia on coronary blood flow and coronary resistance in pigs.
Shimizu M, Konstantinov IE, Kharbanda RK, Cheung MH, Redington AN. / Acta Physiol (Oxf). 2007;190:103-109
Preconditioning and postconditioning: innate cardioprotection from ischemia-reperfusion injury
Dobson GP, Jiang R, Vinten-Johansen J, Zatta AJ, Zhao ZQ / J Appl Physiol 103:1441-1448, 2007
Routine Thrombectomy in Percutaneous Coronary Intervention for Acute ST-Segment–Elevation Myocardial Infarction A Randomized, Controlled Trial
Andersen HR; Bøtker HE; Bøttcher M; Hansen HHT; Kaltoft A; Kristensen J; Kristensen SD; Krusell LR; Lassen JF; Mæng M; Nielsen SS; Nielsen TT; Rasmussen K; Rehling M; Terkelsen C; Thuesen L / Circulation. 2006;114:40-47
Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: First clinical application in humans.
Cheung MM, Kharbanda RK, Konstantinov IE, Shimizu M, Frndova H, Li J, Holtby HM, Cox PN, Smallhorn JF, Van Arsdell GS, Redington AN. / 2006;47:2277-2282
Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: A preclinical study.
Kharbanda RK, Li J, Konstantinov IE, Cheung MM, White PA, Frndova H, Stokoe J, Cox P, Vogel M, Van Arsdell G, MacAllister R, Redington AN. / Heart. 2006;92:1506-1511
Understanding Combat Casualty Care Statistics
Bellamy RF; Champion HR; Holcomb JB; Stansbury LG; Wade C / J Trauma. 2006;60:397–401
Reduction of treatment delay in patients with ST-elevation myocardial infarction: impact of pre-hospital diagnosis and direct referral to primary percutanous coronary intervention
Anderson HR; Ankersen JP; Bendix K; Gerdes JC; Gøtzsche LB; Lassen JF; Nielsen TT; Nørgaard BL; Poulsen H; Rømer, FK; Terkelsen CJ / Terkelsen et al, eur Heart 2005;26:770-7
The remote ischemic preconditioning stimulus modifies gene expression in mouse myocardium.
Konstantinov IE, Arab S, Li J, Coles JG, Boscarino C, Mori A, Cukerman E, Dawood F, Cheung MM, Shimizu M, Liu PP, Redington AN. / J Thorac Cardiovasc Surg. 2005;130:1326-1332
Remote ischemic preconditioning of the recipient reduces myocardial ischemia-reperfusion injury of the denervated donor heart via a katp channel-dependent mechanism.
Konstantinov IE, Li J, Cheung MM, Shimizu M, Stokoe J, Kharbanda RK, Redington AN. / Transplantation. 2005;79:1691-1695
The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans.
Konstantinov IE, Arab S, Kharbanda RK, Li J, Cheung MM, Cherepanov V, Downey GP, Liu PP, Cukerman E, Coles JG, Redington AN. / Physiol Genomics. 2004;19:143-150
A Comparison of Coronary Angioplasty with Fibrinolytic Therapy in Acute Myocardial Infarction
Abildgaard U; Andersen HR; Grande P; Haghfelt T; Husted ST; Kelbaek H; Kjaergard HK; Krusell LR; Lomholt P; Madsen JK; Mortensen LS; Nielsen TT; Pedersen F; Rasmussen K; Thayssen P; Thuesen L; Vigholt E; Villadsen AB / N Engl J Med 2003; 349:733-742
Transient limb ischemia induces remote ischemic preconditioning in vivo.
Kharbanda RK, Mortensen UM, White PA, Kristiansen SB, Schmidt MR, Hoschtitzky JA, Vogel M, Sorensen K, Redington AN, MacAllister R. / Circulation. 2002;106:2881-2883
Ischemic preconditioning at a distance: reduction of myocardial infarct size by partial reduction of blood supply combined with rapid stimulation of the gastrocnemius muscle in the rabbit
Birnbaum Y; Hale SL; Kloner RA / Circulation 96:1641-6 (1997).
Does preconditioning protect the coronary vasculature from subsequent ischemia/reperfusion injury?
Bauer B; Kloner RA; Przyklenk K; Simkhovich BZ / Circulation 1993;88;659-672
Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium
Jennings RB, Murry CE, Reimer KA / Circulation 1986: 74:1124-1136
Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold-blood cardioplegia: a randomised controlled trial
V Venugopal, D J Hausenloy, A Ludman, C Di Salvo, S Kolvekar, J Yap, D Lawrence, J Bognolo, D M Yellon /
Remote Ischemic Limb Preconditioning After Subarachnoid Hemorrhage
Sebastian Koch, MD, Michael Katsnelson, MD, Chuanhui Dong, PhD, and Miguel Perez-Pinzon, PhD /
Remote Ischemic Preconditioning Making the Brain More Tolerant, Safely and Inexpensively
Michael A. Moskowitz, MD; Christian Waeber, PhD /
AHA Heart & Stroke Facts 2003
American Heart Association /
"Heart & Stroke Statistics: 2010 Update At-A-Glance
American Heart Association / "